Promoters as tumour suppressors: MYC vs. PVT1 for gene expression

The collection of genes expressed, when they are expressed and how much they are expressed are what give a cell its personality. Consequently, regulating gene expression is very important and there are many molecular mechanisms through which it is achieved. Understanding these mechanisms provides a clearer picture to deciphering what goes wrong in cells when […]

Read More Promoters as tumour suppressors: MYC vs. PVT1 for gene expression

Putting U in the tail of mRNA

mRNA, the gene transcript that awaits translation, is made of many nucleotides of RNA. These RNA nucleotides can be modified and these modifications can have functional consequences that alters the lifespan of mRNA, its localisation or translation efficiency. Modifications can fall into one of two categories; either nucleotides can be individually targeted or several nucleotides […]

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Translating into the new year. A new role for eIF4A and more methyl modifications

Translation, the conversion of the mRNA code into a polypeptide, is a very important process, one that by now you’d think we would have sussed. However, it is the way with science that with further experiments and improvements in techniques, our opinions on cellular mechanisms can change. The process of translation involves hundreds of factors, […]

Read More Translating into the new year. A new role for eIF4A and more methyl modifications