Exploiting the endogenous: An ADAR way to edit RNA by only adding oligos

Genome editing, with its permanent modification of DNA, necessitates that the editing is conducted both safely and efficiently. An alternative mechanism, that could be both reversible and dose dependent in terms of percentage editing, is to edit at the RNA stage. However, this precise RNA editing faces similar safety and efficiency requirements if it is […]

Read More Exploiting the endogenous: An ADAR way to edit RNA by only adding oligos

Stress eating to death: autophagy is key to tumour suppression on replicative crisis

Wondering “how I am going to afford that?”, breaking something valuable or moments before an important talk/interview are just a few moments where one can become stressed. However, stress to a cell is very different. Have you ever stressed about whether a protein was folded correctly, if there are breaks in your DNA, or whether […]

Read More Stress eating to death: autophagy is key to tumour suppression on replicative crisis

(m)TORC-ing about circadian rhythms at the start of a New Year: a cytoplasmic role for Per2

Now whilst it’s our yearly fashion to celebrate the start of the New Year, to a circadian rhythm, New Year’s Eve is just like any other day. The circadian clock is a cellular internal oscillator that operates through feedback loops coordinating multiple physiological processes. One such activity known to oscillate is of the protein kinase […]

Read More (m)TORC-ing about circadian rhythms at the start of a New Year: a cytoplasmic role for Per2

On the road to success? CellTagging tracks a cell’s journey during direct reprogramming

Direct reprogramming in the context of cells, involves the conversion of one cell type into another. Forexample, a skin cell to a neuron. Only a handful of the large number of cell-type transitions have been tested so far, but what seems apparent is that the processis not that efficient. To improve efficiency, an understanding of […]

Read More On the road to success? CellTagging tracks a cell’s journey during direct reprogramming

Gene recombination in Alzheimer’s disease; An APP-arent correlation in neuronal cells

Currently, world-wide ~44 million people have Alzheimer’s disease (AD). With an ageing population, this number is expected to rise and costs for care could reach $1.1 trillion by 2050. Since recent clinical trials have failed to prevent the progression of the disease, a better understanding of the toxic molecular features that cause neuronal cell death […]

Read More Gene recombination in Alzheimer’s disease; An APP-arent correlation in neuronal cells

Get up to speed with RNA velocity

In a cell, at any particular time, only a subset of genes will be expressed. This subset can vary over time as the cell adapts to both external and internal conditions. Various techniques can be used to determine what these subsets of genes are, information which can be used to understand the function and state […]

Read More Get up to speed with RNA velocity