Featured

Loop it like cohesin

Chromatin, the combination of DNA and protein that resides within our nuclei, takes on a variety of forms. These forms vary depending on the type of cell, the stage of a cell’s cycle and environmental conditions. Techniques to pinpoint regions of chromatin contacts within a nucleus have provided great insight into nuclear organisation and the […]

Read More Loop it like cohesin

Putting U in the tail of mRNA

mRNA, the gene transcript that awaits translation, is made of many nucleotides of RNA. These RNA nucleotides can be modified and these modifications can have functional consequences that alters the lifespan of mRNA, its localisation or translation efficiency. Modifications can fall into one of two categories; either nucleotides can be individually targeted or several nucleotides […]

Read More Putting U in the tail of mRNA

Translating into the new year. A new role for eIF4A and more methyl modifications

Translation, the conversion of the mRNA code into a polypeptide, is a very important process, one that by now you’d think we would have sussed. However, it is the way with science that with further experiments and improvements in techniques, our opinions on cellular mechanisms can change. The process of translation involves hundreds of factors, […]

Read More Translating into the new year. A new role for eIF4A and more methyl modifications

The sex chromosomes – Y is there a Y and the great X-scape

Throughout evolution many mechanisms to determine sex have arisen. Whilst in many species sex is determined genetically, environmental factors such as temperature or even social variables such as size can influence the fate of an organism’s sex. Other species change sex throughout their lifetime. In humans, sex is determined by the sex chromosomes present in […]

Read More The sex chromosomes – Y is there a Y and the great X-scape