Chromatin, the combination of DNA and protein that resides within our nuclei, takes on a variety of forms. These forms vary depending on the type of cell, the stage of a cell’s cycle and environmental conditions. Techniques to pinpoint regions of chromatin contacts within a nucleus have provided great insight into nuclear organisation and the […]Read More Loop it like cohesin
Now maybe it’s the fact I ate too many hot cross buns and crème eggs this Easter, or because it vaguely relates to some exam topics and so can count as revision, but I found myself reading about a drug that reduced the body mass of mice. Yep, this new study by Peng et al. […]Read More A weight loss drug targeting the mRNA demethylase, FTO?
Make a YouTube video on how you wake up at 5 am and all the positive impacts it can have on your life and you are guaranteed to get views. Many of the current videos have millions of hits. Did you know Mark Wahlberg wakes up at 2.30 am*!? Now, whilst I am not denying […]Read More Do your genes dictate whether you’re a morning person?
Out of all of Aesop’s Fables that I know, which I have now realised isn’t that many, “The tortoise and the hare” was always my favourite as a kid. Whilst the fable has been interpreted in different ways, I always took it to mean that slow and steady wins the race. But what race are […]Read More Slow and steady wins the race: uniting eEF2K, translation and lifespan
I think I first came across the news on Twitter. It must’ve been a Monday morning as I was scrolling through my home page. At first I thought this can’t be true. I laughed at how ridiculous the news was. But my laughter soon changed to concern as I began to learn more of the […]Read More He who MUST be named: The #CRISPRbabies 4 months on
If I learnt anything from watching the 2004 film “Mean Girls”, it is that where you sit in the cafeteria is crucial. Okay, whilst not entirely true, the film explains how at high school, everyone fits into different cliques and these dictate the group of people you sit with at lunch; you have your Freshman, […]Read More “Mean Girls” meets Biochemistry – which protein ‘clique’ are you?
Genome editing, with its permanent modification of DNA, necessitates that the editing is conducted both safely and efficiently. An alternative mechanism, that could be both reversible and dose dependent in terms of percentage editing, is to edit at the RNA stage. However, this precise RNA editing faces similar safety and efficiency requirements if it is […]Read More Exploiting the endogenous: An ADAR way to edit RNA by only adding oligos
Wondering “how I am going to afford that?”, breaking something valuable or moments before an important talk/interview are just a few moments where one can become stressed. However, stress to a cell is very different. Have you ever stressed about whether a protein was folded correctly, if there are breaks in your DNA, or whether […]Read More Stress eating to death: autophagy is key to tumour suppression on replicative crisis
Now whilst it’s our yearly fashion to celebrate the start of the New Year, to a circadian rhythm, New Year’s Eve is just like any other day. The circadian clock is a cellular internal oscillator that operates through feedback loops coordinating multiple physiological processes. One such activity known to oscillate is of the protein kinase […]Read More (m)TORC-ing about circadian rhythms at the start of a New Year: a cytoplasmic role for Per2
Direct reprogramming in the context of cells, involves the conversion of one cell type into another. Forexample, a skin cell to a neuron. Only a handful of the large number of cell-type transitions have been tested so far, but what seems apparent is that the processis not that efficient. To improve efficiency, an understanding of […]Read More On the road to success? CellTagging tracks a cell’s journey during direct reprogramming
Currently, world-wide ~44 million people have Alzheimer’s disease (AD). With an ageing population, this number is expected to rise and costs for care could reach $1.1 trillion by 2050. Since recent clinical trials have failed to prevent the progression of the disease, a better understanding of the toxic molecular features that cause neuronal cell death […]Read More Gene recombination in Alzheimer’s disease; An APP-arent correlation in neuronal cells