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Loop it like cohesin

Chromatin, the combination of DNA and protein that resides within our nuclei, takes on a variety of forms. These forms vary depending on the type of cell, the stage of a cell’s cycle and environmental conditions. Techniques to pinpoint regions of chromatin contacts within a nucleus have provided great insight into nuclear organisation and the […]

Read More Loop it like cohesin

On the road to success? CellTagging tracks a cell’s journey during direct reprogramming

Direct reprogramming in the context of cells, involves the conversion of one cell type into another. Forexample, a skin cell to a neuron. Only a handful of the large number of cell-type transitions have been tested so far, but what seems apparent is that the processis not that efficient. To improve efficiency, an understanding of […]

Read More On the road to success? CellTagging tracks a cell’s journey during direct reprogramming

Gene recombination in Alzheimer’s disease; An APP-arent correlation in neuronal cells

Currently, world-wide ~44 million people have Alzheimer’s disease (AD). With an ageing population, this number is expected to rise and costs for care could reach $1.1 trillion by 2050. Since recent clinical trials have failed to prevent the progression of the disease, a better understanding of the toxic molecular features that cause neuronal cell death […]

Read More Gene recombination in Alzheimer’s disease; An APP-arent correlation in neuronal cells

Get up to speed with RNA velocity

In a cell, at any particular time, only a subset of genes will be expressed. This subset can vary over time as the cell adapts to both external and internal conditions. Various techniques can be used to determine what these subsets of genes are, information which can be used to understand the function and state […]

Read More Get up to speed with RNA velocity

Promoters as tumour suppressors: MYC vs. PVT1 for gene expression

The collection of genes expressed, when they are expressed and how much they are expressed are what give a cell its personality. Consequently, regulating gene expression is very important and there are many molecular mechanisms through which it is achieved. Understanding these mechanisms provides a clearer picture to deciphering what goes wrong in cells when […]

Read More Promoters as tumour suppressors: MYC vs. PVT1 for gene expression