Chromatin, the combination of DNA and protein that resides within our nuclei, takes on a variety of forms. These forms vary depending on the type of cell, the stage of a cell’s cycle and environmental conditions. Techniques to pinpoint regions of chromatin contacts within a nucleus have provided great insight into nuclear organisation and the […]Read More Loop it like cohesin
Now whilst it’s our yearly fashion to celebrate the start of the New Year, to a circadian rhythm, New Year’s Eve is just like any other day. The circadian clock is a cellular internal oscillator that operates through feedback loops coordinating multiple physiological processes. One such activity known to oscillate is of the protein kinase […]Read More (m)TORC-ing about circadian rhythms at the start of a New Year: a cytoplasmic role for Per2
Direct reprogramming in the context of cells, involves the conversion of one cell type into another. Forexample, a skin cell to a neuron. Only a handful of the large number of cell-type transitions have been tested so far, but what seems apparent is that the processis not that efficient. To improve efficiency, an understanding of […]Read More On the road to success? CellTagging tracks a cell’s journey during direct reprogramming
Currently, world-wide ~44 million people have Alzheimer’s disease (AD). With an ageing population, this number is expected to rise and costs for care could reach $1.1 trillion by 2050. Since recent clinical trials have failed to prevent the progression of the disease, a better understanding of the toxic molecular features that cause neuronal cell death […]Read More Gene recombination in Alzheimer’s disease; An APP-arent correlation in neuronal cells
After passing through the stomach, the next stage of the digestive system occurs in the small intestine, where nutrients and minerals are absorbed. With a host of digestive enzymes, in addition to a diverse microbiome present, the lining of the small intestine is exposed to quite the ‘chemical soup’ that causes the cells much wear […]Read More The ARTS of life and death in the intestinal stem cells
Want to know what a cell gets up to? How it responds to extracellular signals and/or a transient drug exposure? I think we all do! Looking at which and by how much different genes are transcribed in a cell is a good way to answer these questions, but so far, current approaches, namely RNA-sequencing, only […]Read More Record-seq; Storing a cells transcriptional history with CRISPR
In a cell, at any particular time, only a subset of genes will be expressed. This subset can vary over time as the cell adapts to both external and internal conditions. Various techniques can be used to determine what these subsets of genes are, information which can be used to understand the function and state […]Read More Get up to speed with RNA velocity
Now, as a scientist, or more technically a biochemist, I spend my days learning about DNA, cells and proteins along with their structure, interactions and functions. Work involves either writing essays, reading papers or learning lab techniques. As a student, I also spend time playing sports, watching films and chilling with friends. So, as a […]Read More What all students MUST read – “Rich Dad, Poor Dad”
Memorising facts for exams these days is not enough anymore. Exam techniques including, pulling out the key points from a question, structuring your answers and the dreaded “thinking outside of the box”, are instead being tested. This added stress can become unbearable, but there are strategies and steps that can be taken to circumvent this. […]Read More Are you looking for NSAA and/or A level Biology/Chemistry tuition?
Regardless of the weather, our bodies have evolved to function optimally at 37 ℃. However, we are an insignificant speck of the vast array of species out there, where many, if not most, species are operating at temperatures that could either freeze or frazzle us! Enzymes are the key players in catalysing the many biochemical […]Read More How do enzymes survive the snow? Adapting adenylate kinase to the cold.
The collection of genes expressed, when they are expressed and how much they are expressed are what give a cell its personality. Consequently, regulating gene expression is very important and there are many molecular mechanisms through which it is achieved. Understanding these mechanisms provides a clearer picture to deciphering what goes wrong in cells when […]Read More Promoters as tumour suppressors: MYC vs. PVT1 for gene expression